{"id":13,"slug":"stromal-vascular-fraction","name":"Stromal Vascular Fraction","alternate_names":["SVF","adipose SVF","기질혈관분획","SVF 세포"],"type":"medical","description":"The stromal vascular fraction (SVF) is a heterogeneous mix of cells obtained from adipose tissue after removing mature fat cells; it contains stromal/stem cells, endothelial cells, pericytes and immune cells.","overview":"SVF is produced from liposuctioned fat by enzymatic digestion or mechanical processing and then separated from adipocytes. It is not a purified stem cell product: stem/stromal cells are a minority of the cells. SVF is used in research and in some aesthetic and regenerative procedures, including cell-assisted fat grafting. The composition and clinical value of SVF depend on the processing method and the indication, and regulatory status varies by country. The ISSCR notes that enzymatic or ultrasonic processing of adipose tissue can alter the original function of the cells, so safety and efficacy must be shown for each specific use.","official_url":null,"image_url":null,"country":null,"region":null,"wikidata_id":null,"wikipedia_url":null,"verified":false,"scores":{"authority":78,"trust":0,"citation":0},"topic":{"slug":"svf","name":"SVF & Adipose-derived Cells"},"url":"https://worldwiki.io/entity/stromal-vascular-fraction","facts":[{"id":13,"predicate":"source_tissue","label":"Source tissue","value":"Adipose (fat) tissue obtained by liposuction","unit":null,"confidence":100,"valid_from":null,"valid_until":null,"verified_at":"2026-09-14 13:42:07","source_ids":[20]},{"id":14,"predicate":"composition","label":"Composition","value":"Heterogeneous: stromal/stem cells, endothelial cells, pericytes, immune cells, fibroblasts (mature adipocytes removed)","unit":null,"confidence":100,"valid_from":null,"valid_until":null,"verified_at":"2026-09-14 13:42:07","source_ids":[20]},{"id":15,"predicate":"processing","label":"Processing","value":"Enzymatic digestion or mechanical/ultrasonic processing; the ISSCR notes such processing can alter the original function of the cells","unit":null,"confidence":100,"valid_from":null,"valid_until":null,"verified_at":"2026-09-14 13:42:07","source_ids":[14]},{"id":16,"predicate":"culture_expanded","label":"Culture expansion","value":"No — SVF is freshly isolated, not expanded in culture (unlike ADSC)","unit":null,"confidence":100,"valid_from":null,"valid_until":null,"verified_at":"2026-09-14 13:42:07","source_ids":[20]},{"id":17,"predicate":"regulatory_note","label":"Regulatory note","value":"Regulatory status depends on processing and use; the US FDA has warned consumers about unapproved stem cell products","unit":null,"confidence":100,"valid_from":null,"valid_until":null,"verified_at":"2026-09-14 13:42:07","source_ids":[2]}],"relations":[{"type":"part_of","confidence":100,"target":{"id":11,"slug":"adipose-tissue","name":"Adipose Tissue","type":"medical","description":"Adipose tissue is body fat: a connective tissue made mostly of fat cells (adipocytes) together with blood vessels, immune cells and stromal cells.","url":"https://worldwiki.io/entity/adipose-tissue"}},{"type":"related_to","confidence":100,"target":{"id":12,"slug":"adipose-derived-stem-cell","name":"Adipose-derived Stem Cell","type":"medical","description":"Adipose-derived stem cells (ADSC) are mesenchymal stem/stromal cells isolated from fat tissue and expanded in culture; they are studied for tissue repair and are a component of the stromal vascular fraction.","url":"https://worldwiki.io/entity/adipose-derived-stem-cell"}},{"type":"related_to","confidence":100,"target":{"id":14,"slug":"regenerative-medicine","name":"Regenerative Medicine","type":"concept","description":"Regenerative medicine is a field that aims to repair, replace or regenerate damaged cells, tissues or organs, using approaches such as cell therapy, tissue engineering and biomaterials.","url":"https://worldwiki.io/entity/regenerative-medicine"}},{"type":"related_to","confidence":100,"target":{"id":15,"slug":"cell-viability","name":"Cell Viability","type":"concept","description":"Cell viability is the proportion of living, functional cells in a sample; it is a key quality measure for cell preparations such as SVF before and after processing or freezing.","url":"https://worldwiki.io/entity/cell-viability"}},{"type":"related_to","confidence":100,"target":{"id":19,"slug":"cell-banking","name":"Cell Banking","type":"service","description":"Cell banking is a service that isolates and cryopreserves a person's own cells, such as adipose SVF, for possible future use.","url":"https://worldwiki.io/entity/cell-banking"}},{"type":"related_to","confidence":100,"target":{"id":21,"slug":"autologous-fat-grafting","name":"Autologous Fat Grafting","type":"medical","description":"Autologous fat grafting (fat transfer) is a procedure in which fat is removed from one area of the body by liposuction, processed, and injected into another area to add volume.","url":"https://worldwiki.io/entity/autologous-fat-grafting"}}],"questions":[{"slug":"what-is-svf","question":"What is SVF (stromal vascular fraction)?","intent":"informational","language":"en","short_answer":"Stromal vascular fraction (SVF) is the heterogeneous mix of cells left after mature fat cells are removed from processed adipose tissue. It contains stromal/stem cells, endothelial cells, pericytes and immune cells. SVF is isolated from liposuctioned fat by enzymatic or mechanical processing and is used in research and in some fat grafting procedures. It is not a purified stem cell product, and its composition depends on the processing method.","url":"https://worldwiki.io/q/what-is-svf"},{"slug":"svf-vs-stem-cells-same","question":"Are SVF and stem cells the same thing?","intent":"comparison","language":"en","short_answer":"No. SVF is a mixed population of cells from fat tissue that contains some stem/stromal cells along with endothelial, immune and other cells. \"Stem cells\" in marketing usually refers to adipose-derived stem cells (ADSC), which are a subset of SVF, often expanded in culture. SVF is freshly isolated and not expanded, so it contains far fewer stem cells per dose than a cultured ADSC product.","url":"https://worldwiki.io/q/svf-vs-stem-cells-same"},{"slug":"svf-vs-adsc-difference","question":"What is the difference between SVF and ADSC?","intent":"comparison","language":"en","short_answer":"SVF (stromal vascular fraction) is the whole cell mixture isolated from fat in one session without culture. ADSC (adipose-derived stem cells) are the mesenchymal stem/stromal cells within SVF, usually purified by growing them in culture for days to weeks. SVF is faster and often processed at the point of care; ADSC products are more uniform but are regulated as manufactured biologics in most countries.","url":"https://worldwiki.io/q/svf-vs-adsc-difference"},{"slug":"what-is-adipose-derived-svf","question":"What is adipose-derived SVF?","intent":"informational","language":"en","short_answer":"Adipose-derived SVF is the stromal vascular fraction taken from a person's own fat tissue. Fat is removed by liposuction, processed to separate fat cells from the remaining cells, and the resulting cell fraction is used, for example to enrich a fat graft. \"Adipose-derived\" simply names the tissue source; SVF is not obtained from bone marrow or blood.","url":"https://worldwiki.io/q/what-is-adipose-derived-svf"},{"slug":"svf란-무엇인가","question":"SVF란 무엇인가?","intent":"informational","language":"ko","short_answer":"SVF(Stromal Vascular Fraction, 기질혈관분획)는 지방조직에서 성숙 지방세포를 제거한 뒤 남는 이질적인 세포 집단입니다. 기질·줄기세포, 혈관내피세포, 혈관주위세포, 면역세포가 섞여 있으며 지방흡입으로 얻은 지방을 효소 또는 물리적으로 처리해 분리합니다. 정제된 줄기세포 제품이 아니며 구성은 처리 방법에 따라 달라지고, 임상 활용의 안전성과 효과는 적용 분야별로 따로 평가해야 합니다.","url":"https://worldwiki.io/q/svf란-무엇인가"}],"sources":[{"id":20,"title":"Safety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature review","url":"https://pubmed.ncbi.nlm.nih.gov/41618435/","publisher":"Stem Cell Research & Therapy (2026)","type":"academic","publication_date":"2026-01-01","accessed_at":"2026-09-14 13:42:07"},{"id":14,"title":"ISSCR Guidelines for Stem Cell Research and Clinical Translation","url":"https://www.isscr.org/guidelines","publisher":"International Society for Stem Cell Research","type":"academic","publication_date":null,"accessed_at":"2026-09-14 13:42:07"},{"id":2,"title":"FDA Warns About Stem Cell Therapies","url":"https://www.fda.gov/consumers/consumer-updates/fda-warns-about-stem-cell-therapies","publisher":"U.S. Food and Drug Administration","type":"government","publication_date":null,"accessed_at":"2026-09-14 13:42:07"}],"providers":[{"slug":"sc301","name":"SC301의원","verified_level":"verified","sponsored":false,"featured":false,"country":"KR","city":"Seoul","url":"https://worldwiki.io/provider/sc301"}],"published_at":"2026-09-14 13:42:07","updated_at":"2026-09-14 22:42:07","verified_at":null}