{"id":699,"slug":"do-stem-cells-improve-fat-graft-survival-through-angiogenesis","question":"Do stem cells improve fat graft survival through angiogenesis?","intent":"informational","language":"en","url":"https://worldwiki.io/q/do-stem-cells-improve-fat-graft-survival-through-angiogenesis","entity":{"slug":"angiogenesis","name":"Angiogenesis","url":"https://worldwiki.io/entity/angiogenesis"},"answer":{"short_answer":"This is a hypothesis, not a proven mechanism. Researchers behind cell-assisted lipotransfer proposed that adipose-derived stromal cells may help new vessels grow into the graft. They might do this by turning into endothelial cells or by releasing growth factors. Some clinical studies report better volume retention with cell-enriched grafts. However, the studies vary widely in their methods, and the evidence on how vessels form in the graft is limited.","detailed_answer":"<p>The original 2008 study had 40 patients and no control group <span class=\"ref\">[7]</span>. A 2025 systematic review of 12 studies called for larger long-term randomized trials <span class=\"ref\">[8]</span>.</p>","format":"paragraph","confidence":75,"verified_at":"2026-09-18 07:10:23","updated_at":"2026-09-18 16:10:23"},"sources":[{"id":146,"title":"Angiogenesis Inhibitors (fact sheet)","url":"https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet","publisher":"National Cancer Institute","type":"government","accessed_at":"2026-09-18 18:01:05"},{"id":147,"title":"Overview of Angiogenesis (in: Adair TH, Montani JP. Angiogenesis)","url":"https://www.ncbi.nlm.nih.gov/books/NBK53238/","publisher":"Morgan & Claypool Life Sciences / NCBI Bookshelf","type":"journal","accessed_at":"2026-09-18 18:01:06"},{"id":148,"title":"Bevacizumab (StatPearls)","url":"https://www.ncbi.nlm.nih.gov/books/NBK482126/","publisher":"StatPearls Publishing / NCBI Bookshelf","type":"journal","accessed_at":"2026-09-18 18:01:07"},{"id":149,"title":"Tumor Angiogenesis (editorial), Dudek AZ, Gupta K, Ramakrishnan S, Mukhopadhyay D. Journal of Oncology","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2945670/","publisher":"Journal of Oncology (Hindawi)","type":"journal","accessed_at":"2026-09-18 18:01:08"},{"id":150,"title":"Treatments for Wet AMD (Advanced Neovascular AMD)","url":"https://www.nei.nih.gov/eye-health-information/eye-conditions-and-diseases/age-related-macular-degeneration/treatments-wet-amd-advanced-neovascular-amd","publisher":"National Eye Institute (NIH)","type":"government","accessed_at":"2026-09-18 18:01:09"},{"id":151,"title":"Therapeutic Angiogenesis for Peripheral Artery Disease: Lessons Learned in Translational Science, Iyer SR, Annex BH","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5802410/","publisher":"JACC: Basic to Translational Science","type":"journal","accessed_at":"2026-09-18 18:01:10"},{"id":152,"title":"Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al.","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2175019/","publisher":"Aesthetic Plastic Surgery","type":"journal","accessed_at":"2026-09-18 18:01:10"},{"id":145,"title":"Adipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional Outcomes","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12812246/","publisher":"Cureus (PubMed Central)","type":"journal","accessed_at":"2026-09-18 18:01:04"}],"published_at":"2026-09-18 07:10:23"}