{"id":644,"slug":"what-diseases-are-treated-with-adult-stem-cells","question":"What diseases are treated with adult stem cells?","intent":"informational","language":"en","url":"https://worldwiki.io/q/what-diseases-are-treated-with-adult-stem-cells","entity":{"slug":"adult-stem-cell","name":"Adult Stem Cell","url":"https://worldwiki.io/entity/adult-stem-cell"},"answer":{"short_answer":"The established use is hematopoietic stem cell transplantation for blood cancers such as leukaemia, lymphoma and myeloma, and for some bone marrow and immune disorders. Skin grafts and corneal stem cell grafts for eye burns are also recognised. A bone-marrow-derived MSC product is approved in the US for steroid-refractory acute graft-versus-host disease in children. Most other claimed uses are unproven.","detailed_answer":"<p>In 2018, 93,105 hematopoietic cell transplants were reported worldwide <span class=\"ref\">[5]</span>. Holoclar is authorised in the EU for limbal stem cell deficiency <span class=\"ref\">[11]</span>, and Ryoncil was approved by the FDA in December 2024 <span class=\"ref\">[7]</span>.</p>","format":"paragraph","confidence":75,"verified_at":"2026-09-18 06:21:20","updated_at":"2026-09-18 15:21:20"},"sources":[{"id":106,"title":"Adult Stem Cells – Stem Cells and the Future of Regenerative Medicine","url":"https://www.ncbi.nlm.nih.gov/books/NBK223693/","publisher":"National Research Council and Institute of Medicine (National Academies Press, via NCBI Bookshelf)","type":"journal","accessed_at":"2026-09-19 18:01:31"},{"id":107,"title":"Multipotent to Pluripotent Properties of Adult Stem Cells","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3876920/","publisher":"Stem Cells International (Hindawi), via PubMed Central","type":"journal","accessed_at":"2026-09-19 18:01:31"},{"id":108,"title":"Adult stem cells and their trans-differentiation potential—perspectives and therapeutic applications","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2954191/","publisher":"Journal of Molecular Medicine (Hombach-Klonisch et al.), via PubMed Central","type":"journal","accessed_at":"2026-09-19 18:01:31"},{"id":109,"title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","url":"https://pubmed.ncbi.nlm.nih.gov/16923606/","publisher":"Cytotherapy 8(4):315-317 (Dominici et al.)","type":"academic","accessed_at":"2026-09-19 18:01:32"},{"id":110,"title":"Continuous and differential improvement in worldwide access to hematopoietic cell transplantation: activity has doubled in a decade with a notable increase in unrelated and non-identical related donors","url":"https://haematologica.org/article/view/haematol.2024.285002","publisher":"Haematologica (Atsuta et al.)","type":"journal","accessed_at":"2026-09-19 18:01:33"},{"id":98,"title":"One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors (Niederwieser D, et al., Haematologica 107(5):1045-1053)","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9052915/","publisher":"Haematologica","type":"journal","accessed_at":"2026-09-19 18:01:25"},{"id":111,"title":"FDA approves remestemcel-L-rknd for steroid-refractory acute graft versus host disease in pediatric patients","url":"https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-remestemcel-l-rknd-steroid-refractory-acute-graft-versus-host-disease-pediatric","publisher":"U.S. Food and Drug Administration","type":"government","accessed_at":"2026-09-18 18:00:49"},{"id":112,"title":"Consumer Alert on Regenerative Medicine Products Including Stem Cells and Exosomes","url":"https://www.fda.gov/vaccines-blood-biologics/consumers-biologics/consumer-alert-regenerative-medicine-products-including-stem-cells-and-exosomes","publisher":"U.S. Food and Drug Administration","type":"government","accessed_at":"2026-09-18 18:00:49"},{"id":113,"title":"Patient and Consumer Warning about Potential Serious Risks of Harm following Use of Unapproved Products from Human Cells or Tissues","url":"https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/patient-and-consumer-warning-about-potential-serious-risks-harm-following-use-unapproved-products","publisher":"U.S. Food and Drug Administration","type":"government","accessed_at":"2026-09-18 18:00:49"},{"id":114,"title":"First stem-cell therapy recommended for approval in EU (press release)","url":"https://www.ema.europa.eu/en/documents/press-release/first-stem-cell-therapy-recommended-approval-eu_en.pdf","publisher":"European Medicines Agency","type":"government","accessed_at":"2026-09-19 18:01:34"},{"id":115,"title":"Holoclar – EPAR","url":"https://www.ema.europa.eu/en/medicines/human/EPAR/holoclar","publisher":"European Medicines Agency","type":"government","accessed_at":"2026-09-19 18:01:35"},{"id":99,"title":"Stem Cell Resources for Patients","url":"https://www.isscr.org/patients","publisher":"International Society for Stem Cell Research (ISSCR)","type":"organization","accessed_at":"2026-09-19 18:01:26"}],"published_at":"2026-09-18 06:21:20"}