{"id":698,"slug":"what-is-vegf-and-what-does-it-do-in-angiogenesis","question":"What is VEGF and what does it do in angiogenesis?","intent":"informational","language":"en","url":"https://worldwiki.io/q/what-is-vegf-and-what-does-it-do-in-angiogenesis","entity":{"slug":"angiogenesis","name":"Angiogenesis","url":"https://worldwiki.io/entity/angiogenesis"},"answer":{"short_answer":"Vascular endothelial growth factor (VEGF) is a signaling protein. Its main form, VEGF-A, is the principal signal that switches angiogenesis on. Cells that are short of oxygen release it, and it draws new vessels toward the tissue that needs them. Losing half of normal VEGF-A is fatal to the embryo. Drugs that block VEGF, such as bevacizumab and anti-VEGF eye injections, are used in some cancers and in wet macular degeneration.","detailed_answer":"<p>For the biology, see <span class=\"ref\">[2]</span>. For the drug that binds VEGF-A, see <span class=\"ref\">[3]</span>. For the use of anti-VEGF injections in wet AMD, see <span class=\"ref\">[5]</span>.</p>","format":"paragraph","confidence":75,"verified_at":"2026-09-18 07:10:23","updated_at":"2026-09-18 16:10:23"},"sources":[{"id":146,"title":"Angiogenesis Inhibitors (fact sheet)","url":"https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet","publisher":"National Cancer Institute","type":"government","accessed_at":"2026-09-18 18:01:05"},{"id":147,"title":"Overview of Angiogenesis (in: Adair TH, Montani JP. Angiogenesis)","url":"https://www.ncbi.nlm.nih.gov/books/NBK53238/","publisher":"Morgan & Claypool Life Sciences / NCBI Bookshelf","type":"journal","accessed_at":"2026-09-18 18:01:06"},{"id":148,"title":"Bevacizumab (StatPearls)","url":"https://www.ncbi.nlm.nih.gov/books/NBK482126/","publisher":"StatPearls Publishing / NCBI Bookshelf","type":"journal","accessed_at":"2026-09-18 18:01:07"},{"id":149,"title":"Tumor Angiogenesis (editorial), Dudek AZ, Gupta K, Ramakrishnan S, Mukhopadhyay D. Journal of Oncology","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2945670/","publisher":"Journal of Oncology (Hindawi)","type":"journal","accessed_at":"2026-09-18 18:01:08"},{"id":150,"title":"Treatments for Wet AMD (Advanced Neovascular AMD)","url":"https://www.nei.nih.gov/eye-health-information/eye-conditions-and-diseases/age-related-macular-degeneration/treatments-wet-amd-advanced-neovascular-amd","publisher":"National Eye Institute (NIH)","type":"government","accessed_at":"2026-09-18 18:01:09"},{"id":151,"title":"Therapeutic Angiogenesis for Peripheral Artery Disease: Lessons Learned in Translational Science, Iyer SR, Annex BH","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5802410/","publisher":"JACC: Basic to Translational Science","type":"journal","accessed_at":"2026-09-18 18:01:10"},{"id":152,"title":"Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al.","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2175019/","publisher":"Aesthetic Plastic Surgery","type":"journal","accessed_at":"2026-09-18 18:01:10"},{"id":145,"title":"Adipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional Outcomes","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12812246/","publisher":"Cureus (PubMed Central)","type":"journal","accessed_at":"2026-09-18 18:01:04"}],"published_at":"2026-09-18 07:10:23"}