{"id":643,"slug":"where-are-adult-stem-cells-found-in-the-body","question":"Where are adult stem cells found in the body?","intent":"informational","language":"en","url":"https://worldwiki.io/q/where-are-adult-stem-cells-found-in-the-body","entity":{"slug":"adult-stem-cell","name":"Adult Stem Cell","url":"https://worldwiki.io/entity/adult-stem-cell"},"answer":{"short_answer":"Adult stem cells are found in many organs, including bone marrow, skin, gut, skeletal muscle, brain and the rim of the cornea. Mesenchymal stromal cells can also be isolated from fat tissue, umbilical cord Wharton's jelly and dental pulp. The cells usually sit in a specialised microenvironment, or niche, which controls when they divide and when they produce mature cells.","detailed_answer":"<p>Tissue locations are described by the National Academies report <span class=\"ref\">[1]</span> and by reviews <span class=\"ref\">[2]</span><span class=\"ref\">[3]</span>. Limbal stem cells sit at the edge of the cornea <span class=\"ref\">[10]</span>.</p>","format":"paragraph","confidence":75,"verified_at":"2026-09-18 06:21:20","updated_at":"2026-09-18 15:21:20"},"sources":[{"id":106,"title":"Adult Stem Cells – Stem Cells and the Future of Regenerative Medicine","url":"https://www.ncbi.nlm.nih.gov/books/NBK223693/","publisher":"National Research Council and Institute of Medicine (National Academies Press, via NCBI Bookshelf)","type":"journal","accessed_at":"2026-09-19 18:01:31"},{"id":107,"title":"Multipotent to Pluripotent Properties of Adult Stem Cells","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3876920/","publisher":"Stem Cells International (Hindawi), via PubMed Central","type":"journal","accessed_at":"2026-09-19 18:01:31"},{"id":108,"title":"Adult stem cells and their trans-differentiation potential—perspectives and therapeutic applications","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2954191/","publisher":"Journal of Molecular Medicine (Hombach-Klonisch et al.), via PubMed Central","type":"journal","accessed_at":"2026-09-19 18:01:31"},{"id":109,"title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","url":"https://pubmed.ncbi.nlm.nih.gov/16923606/","publisher":"Cytotherapy 8(4):315-317 (Dominici et al.)","type":"academic","accessed_at":"2026-09-19 18:01:32"},{"id":110,"title":"Continuous and differential improvement in worldwide access to hematopoietic cell transplantation: activity has doubled in a decade with a notable increase in unrelated and non-identical related donors","url":"https://haematologica.org/article/view/haematol.2024.285002","publisher":"Haematologica (Atsuta et al.)","type":"journal","accessed_at":"2026-09-19 18:01:33"},{"id":98,"title":"One and a half million hematopoietic stem cell transplants: continuous and differential improvement in worldwide access with the use of non-identical family donors (Niederwieser D, et al., Haematologica 107(5):1045-1053)","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9052915/","publisher":"Haematologica","type":"journal","accessed_at":"2026-09-19 18:01:25"},{"id":111,"title":"FDA approves remestemcel-L-rknd for steroid-refractory acute graft versus host disease in pediatric patients","url":"https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-remestemcel-l-rknd-steroid-refractory-acute-graft-versus-host-disease-pediatric","publisher":"U.S. Food and Drug Administration","type":"government","accessed_at":"2026-09-18 18:00:49"},{"id":112,"title":"Consumer Alert on Regenerative Medicine Products Including Stem Cells and Exosomes","url":"https://www.fda.gov/vaccines-blood-biologics/consumers-biologics/consumer-alert-regenerative-medicine-products-including-stem-cells-and-exosomes","publisher":"U.S. Food and Drug Administration","type":"government","accessed_at":"2026-09-18 18:00:49"},{"id":113,"title":"Patient and Consumer Warning about Potential Serious Risks of Harm following Use of Unapproved Products from Human Cells or Tissues","url":"https://www.fda.gov/vaccines-blood-biologics/safety-availability-biologics/patient-and-consumer-warning-about-potential-serious-risks-harm-following-use-unapproved-products","publisher":"U.S. Food and Drug Administration","type":"government","accessed_at":"2026-09-18 18:00:49"},{"id":114,"title":"First stem-cell therapy recommended for approval in EU (press release)","url":"https://www.ema.europa.eu/en/documents/press-release/first-stem-cell-therapy-recommended-approval-eu_en.pdf","publisher":"European Medicines Agency","type":"government","accessed_at":"2026-09-19 18:01:34"},{"id":115,"title":"Holoclar – EPAR","url":"https://www.ema.europa.eu/en/medicines/human/EPAR/holoclar","publisher":"European Medicines Agency","type":"government","accessed_at":"2026-09-19 18:01:35"},{"id":99,"title":"Stem Cell Resources for Patients","url":"https://www.isscr.org/patients","publisher":"International Society for Stem Cell Research (ISSCR)","type":"organization","accessed_at":"2026-09-19 18:01:26"}],"published_at":"2026-09-18 06:21:20"}