{"id":697,"slug":"why-do-tumors-need-angiogenesis","question":"Why do tumors need angiogenesis?","intent":"informational","language":"en","url":"https://worldwiki.io/q/why-do-tumors-need-angiogenesis","entity":{"slug":"angiogenesis","name":"Angiogenesis","url":"https://worldwiki.io/entity/angiogenesis"},"answer":{"short_answer":"Solid tumors need their own blood supply to grow larger than a few millimeters. They release chemical signals, or prompt nearby cells to release them, which cause new vessels to grow toward the tumor. These vessels bring oxygen and nutrients, letting the tumor grow, invade nearby tissue and spread to other organs. Judah Folkman proposed in 1971 that blocking this process could be a cancer treatment.","detailed_answer":"<p>NCI explains the role of angiogenesis in tumor growth <span class=\"ref\">[1]</span>. Folkman's postulates, including the limit of about 2–3 mm³ without new vessels, are summarized in a 2010 editorial <span class=\"ref\">[4]</span>.</p>","format":"paragraph","confidence":75,"verified_at":"2026-09-18 07:10:23","updated_at":"2026-09-18 16:10:23"},"sources":[{"id":146,"title":"Angiogenesis Inhibitors (fact sheet)","url":"https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet","publisher":"National Cancer Institute","type":"government","accessed_at":"2026-09-18 18:01:05"},{"id":147,"title":"Overview of Angiogenesis (in: Adair TH, Montani JP. Angiogenesis)","url":"https://www.ncbi.nlm.nih.gov/books/NBK53238/","publisher":"Morgan & Claypool Life Sciences / NCBI Bookshelf","type":"journal","accessed_at":"2026-09-18 18:01:06"},{"id":148,"title":"Bevacizumab (StatPearls)","url":"https://www.ncbi.nlm.nih.gov/books/NBK482126/","publisher":"StatPearls Publishing / NCBI Bookshelf","type":"journal","accessed_at":"2026-09-18 18:01:07"},{"id":149,"title":"Tumor Angiogenesis (editorial), Dudek AZ, Gupta K, Ramakrishnan S, Mukhopadhyay D. Journal of Oncology","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2945670/","publisher":"Journal of Oncology (Hindawi)","type":"journal","accessed_at":"2026-09-18 18:01:08"},{"id":150,"title":"Treatments for Wet AMD (Advanced Neovascular AMD)","url":"https://www.nei.nih.gov/eye-health-information/eye-conditions-and-diseases/age-related-macular-degeneration/treatments-wet-amd-advanced-neovascular-amd","publisher":"National Eye Institute (NIH)","type":"government","accessed_at":"2026-09-18 18:01:09"},{"id":151,"title":"Therapeutic Angiogenesis for Peripheral Artery Disease: Lessons Learned in Translational Science, Iyer SR, Annex BH","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5802410/","publisher":"JACC: Basic to Translational Science","type":"journal","accessed_at":"2026-09-18 18:01:10"},{"id":152,"title":"Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al.","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2175019/","publisher":"Aesthetic Plastic Surgery","type":"journal","accessed_at":"2026-09-18 18:01:10"},{"id":145,"title":"Adipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional Outcomes","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12812246/","publisher":"Cureus (PubMed Central)","type":"journal","accessed_at":"2026-09-18 18:01:04"}],"published_at":"2026-09-18 07:10:23"}