{"id":965,"slug":"孩子患克罗恩病-肛瘘反复不愈-有没有脂肪干细胞用于儿童的研究","question":"孩子患克罗恩病，肛瘘反复不愈，有没有脂肪干细胞用于儿童的研究？","intent":"research","language":"zh","url":"https://worldwiki.io/q/孩子患克罗恩病-肛瘘反复不愈-有没有脂肪干细胞用于儿童的研究","entity":{"slug":"adipose-derived-stem-cell","name":"Adipose-derived Stem Cell","url":"https://worldwiki.io/entity/adipose-derived-stem-cell"},"answer":{"short_answer":"有一项韩国的IV期（上市后）临床研究，考察了自体脂肪组织来源干细胞（Anterogen）治疗儿童难治性克罗恩病复杂肛瘘的疗效与安全性。本页资料只记录了该研究的存在与设计范畴，未收录具体的入组人数、缓解率等结果数据，需要就诊时请医生对照原始论文与患儿情况判断。[9][5]","detailed_answer":"<p>该研究为上市后（IV期）研究，对象为难治性克罗恩病复杂肛瘘的儿童患者，使用的是Anterogen的自体脂肪来源干细胞产品；相关产品Cupistem于2012年经韩国MFDS批准用于克罗恩病肛瘘。[9][5]</p><p>本页未收录该研究的具体疗效数值。若要评估，建议向消化科或小儿外科医生索取该论文原文（Annals of Surgical Treatment and Research，Cho YJ等），并确认：是否为已批准适应症内使用、年龄是否在批准范围内、有无可查询的试验注册号。[9]</p>","format":"paragraph","confidence":75,"verified_at":null,"updated_at":"2026-09-20 17:11:10"},"sources":[{"id":248,"title":"Efficacy and safety of autologous adipose tissue-derived stem cell therapy for children with refractory Crohn's complex fistula: a Phase IV clinical study","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8255577/","publisher":"Annals of Surgical Treatment and Research (Cho YJ et al.; via PubMed Central)","type":"journal","accessed_at":"2026-09-19 18:00:20"},{"id":101,"title":"Mesenchymal Stem Cell Therapies Approved by Regulatory Agencies around the World (Fernández-Garza LE, et al., Pharmaceuticals 16(9):1334)","url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10536665/","publisher":"Pharmaceuticals (MDPI)","type":"journal","accessed_at":"2026-09-19 18:01:27"}],"published_at":"2026-09-20 08:11:10"}