---
title: "What are the side effects of angiogenesis inhibitors?"
url: "https://worldwiki.io/q/what-are-the-side-effects-of-angiogenesis-inhibitors"
type: "question"
language: "en"
intent: "informational"
entity: "Angiogenesis"
topic: "SVF & Adipose-derived Cells"
published: "2026-09-18 07:10:23"
updated: "2026-10-08 09:18:06"
---

# What are the side effects of angiogenesis inhibitors?

## Short answer

NCI lists these common side effects of angiogenesis inhibitors: bleeding, clots in the arteries, high blood pressure, slow wound healing and protein in the urine. Drugs that target VEGF receptors can also cause fatigue, diarrhea, thyroid problems and hand-foot syndrome. Rare but serious problems include tears in the gut wall and fistulas. For bevacizumab, reported rates of high blood pressure range from 19% to 42%.

## Answer

For the side-effect list, see [1]. For bevacizumab-specific rates, see [3]. These drugs are prescribed and monitored by specialists.

### Stem cells in cosmetic surgery

In cosmetic surgery, "stem cell" procedures almost always use [adipose-derived stem cells](/entity/adipose-derived-stem-cell). The stromal vascular fraction (SVF), which contains them, is separated from liposuctioned fat and mixed into the fat being grafted, as in [stem cell breast augmentation](/entity/stem-cell-breast-augmentation) and [stem cell fat grafting](/entity/stem-cell-fat-grafting).

## Related questions

- [Why do tumors need angiogenesis?](https://worldwiki.io/q/why-do-tumors-need-angiogenesis)
- [What is the difference between angiogenesis and vasculogenesis?](https://worldwiki.io/q/what-is-the-difference-between-angiogenesis-and-vasculogenesis)
- [What is VEGF and what does it do in angiogenesis?](https://worldwiki.io/q/what-is-vegf-and-what-does-it-do-in-angiogenesis)
- [Do stem cells improve fat graft survival through angiogenesis?](https://worldwiki.io/q/do-stem-cells-improve-fat-graft-survival-through-angiogenesis)

## Sources

1. [Angiogenesis Inhibitors (fact sheet)](https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet) — National Cancer Institute · evidence page: https://worldwiki.io/source/146
2. [Overview of Angiogenesis (in: Adair TH, Montani JP. Angiogenesis)](https://www.ncbi.nlm.nih.gov/books/NBK53238/) — Morgan & Claypool Life Sciences / NCBI Bookshelf · evidence page: https://worldwiki.io/source/147
3. [Bevacizumab (StatPearls)](https://www.ncbi.nlm.nih.gov/books/NBK482126/) — StatPearls Publishing / NCBI Bookshelf · evidence page: https://worldwiki.io/source/148
4. [Tumor Angiogenesis (editorial), Dudek AZ, Gupta K, Ramakrishnan S, Mukhopadhyay D. Journal of Oncology](https://pmc.ncbi.nlm.nih.gov/articles/PMC2945670/) — Journal of Oncology (Hindawi) · evidence page: https://worldwiki.io/source/149
5. [Treatments for Wet AMD (Advanced Neovascular AMD)](https://www.nei.nih.gov/eye-health-information/eye-conditions-and-diseases/age-related-macular-degeneration/treatments-wet-amd-advanced-neovascular-amd) — National Eye Institute (NIH) · evidence page: https://worldwiki.io/source/150
6. [Therapeutic Angiogenesis for Peripheral Artery Disease: Lessons Learned in Translational Science, Iyer SR, Annex BH](https://pmc.ncbi.nlm.nih.gov/articles/PMC5802410/) — JACC: Basic to Translational Science · evidence page: https://worldwiki.io/source/151
7. [Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al.](https://pmc.ncbi.nlm.nih.gov/articles/PMC2175019/) — Aesthetic Plastic Surgery · evidence page: https://worldwiki.io/source/152
8. [Adipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional Outcomes](https://pmc.ncbi.nlm.nih.gov/articles/PMC12812246/) — Cureus (PubMed Central) · evidence page: https://worldwiki.io/source/145