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의료 · Plastic Surgery

SVF Facial Fat Grafting

다른 이름: SVF 얼굴 지방이식, SVF 얼굴성형

발행 2026년 9월 14일갱신 2026년 11월 12일
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정의

SVF facial fat grafting is facial fat transfer with the graft enriched by stromal vascular fraction.

빠른 답변

What is SVF facial fat grafting?

SVF facial fat grafting is facial fat transfer in which the injected fat is enriched with stromal vascular fraction isolated from part of the harvested fat. The rationale is the same as for cell-assisted grafting elsewhere: added stromal cells may support graft survival. Evidence for the face comes mainly from small series rather than large controlled trials.

검증 2026년 9월 15일

핵심 사실

항목값출처
DefinitionCell-assisted lipotransfer: SVF is isolated from half of the harvested fat and recombined with the remaining fat before injection[1]journalCell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells (Yoshimura K et al., Dermatologic Surgery; Europe PMC record)Wiley / Europe PMC
First facial clinical report2008, Yoshimura et al. (University of Tokyo), Dermatologic Surgery 34(9); facial lipoatrophy, 3 CAL vs 3 conventional patients[1]journalCell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells (Yoshimura K et al., Dermatologic Surgery; Europe PMC record)Wiley / Europe PMC
Pooled retention difference (all sites)SVF-enriched grafts: +17.20 percentage points in mean retention vs conventional (95% CI 11.26–23.15); 18 studies, 893 patients; authors call for more standardized RCTs %기준 2026년 1월 1일[1]journalCell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells (Yoshimura K et al., Dermatologic Surgery; Europe PMC record)Wiley / Europe PMC
Reported safetyNo serious adverse events attributed to SVF enrichment in the included studies (follow-up up to 4 years); minor bruising and swelling; nonrandomized studies at serious risk of bias기준 2025년 1월 1일[2]journalAdipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional OutcomesCureus (PubMed Central)
SVF isolation methodsEnzymatic (collagenase) or mechanical; mechanical isolation gives lower total cell yield but comparable viability기준 2025년 1월 1일[3]journalMechanical isolation of stromal vascular fraction from adipose tissue: methods and cellular outcomes: a systematic review and meta-analysisStem Cell Research & Therapy (via PubMed Central)
US regulatory positionFDA stated that processing adipose tissue into SVF is more than minimal manipulation, that the same-surgical-procedure exception does not apply, and that a BLA or IND is required기준 2017년 8월 24일[4]governmentWarning Letter: US Stem Cell Clinic, LLC (524470)U.S. Food and Drug Administration
Applicable FDA guidanceRegulatory Considerations for HCT/Ps: Minimal Manipulation and Homologous Use (docket FDA-2017-D-6146)기준 2020년 7월 1일[5]governmentRegulatory Considerations for Human Cells, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous UseU.S. Food and Drug Administration
Korean institution designationMOHW designates advanced regenerative medicine institutions (첨단재생의료실시기관) for high-risk cell therapy; MFDS separately licenses cell-processing facilities기준 2026년 6월 12일[6]news줄기세포 가슴성형, 복지부‧식약처 인증기관에서 받으면 ‘안심’Sports Kyunghyang

개요

SVF facial fat grafting, also called cell-assisted lipotransfer, is autologous fat transfer to the face in which the stromal vascular fraction (a cell mix including adipose-derived stromal cells) is isolated from part of the lipoaspirate by collagenase digestion or mechanical processing and added to the injected fat. It is used for facial lipoatrophy, contour deficits and volume restoration, on the rationale that the cells support graft survival. Systematic reviews report higher retention than plain fat grafting, but most studies are small, heterogeneous and of weak quality. The US FDA treats enzymatically processed SVF as more than minimally manipulated, requiring an IND or biologics licence; in Korea, cell-based procedures may fall under the Advanced Regenerative Bio Act. Readers should verify the isolation method, the provider's regulatory status and how retention was measured.

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SC301의원

SC301의원 (SC301 Clinic) is a plastic surgery clinic in Gangnam, Seoul, South Korea whose official site presents SVF (stromal vascular fraction) fat grafting for the breast and face, liposuction, lifting and cell banking as its main services.

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참고 출처

독립 출처 비율 100% (11/11)
등급 A · 3등급 B · 6등급 C · 1등급 D · 1
  1. 등급 B · journalCell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells (Yoshimura K et al., Dermatologic Surgery; Europe PMC record) — Wiley / Europe PMC · 확인일 2026년 10월 29일 · 근거 페이지
  2. 등급 B · journalAdipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional Outcomes — Cureus (PubMed Central) · 확인일 2026년 11월 10일 · 근거 페이지
  3. 등급 B · journalMechanical isolation of stromal vascular fraction from adipose tissue: methods and cellular outcomes: a systematic review and meta-analysis — Stem Cell Research & Therapy (via PubMed Central) · 확인일 2026년 11월 12일 · 근거 페이지
  4. 등급 A · governmentWarning Letter: US Stem Cell Clinic, LLC (524470) — U.S. Food and Drug Administration · 확인일 2026년 11월 10일 · 근거 페이지
  5. 등급 A · governmentRegulatory Considerations for Human Cells, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous Use — U.S. Food and Drug Administration · 확인일 2026년 11월 10일 · 근거 페이지
  6. 등급 D · news줄기세포 가슴성형, 복지부‧식약처 인증기관에서 받으면 ‘안심’ — Sports Kyunghyang · 확인일 2026년 11월 12일 · 근거 페이지
  7. 등급 B · academicCell-Assisted Lipotransfer: A Systematic Review of its Efficacy — Aesthetic Plastic Surgery (2024) · 확인일 2026년 11월 12일 · 근거 페이지
  8. 등급 B · academicSafety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature review — Stem Cell Research & Therapy (2026) · 확인일 2026년 11월 12일 · 근거 페이지
  9. 등급 B · academicAdvancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies — Frontiers in Cell and Developmental Biology (2026) · 확인일 2026년 11월 12일 · 근거 페이지
  10. 등급 C · organizationISSCR Guidelines for Stem Cell Research and Clinical Translation — International Society for Stem Cell Research · 확인일 2026년 11월 12일 · 근거 페이지
  11. 등급 A · governmentFDA Warns About Stem Cell Therapies — U.S. Food and Drug Administration · 확인일 2026년 9월 15일 · 근거 페이지
변경 이력
최초 발행 · 2026년 9월 14일