SVF Facial Fat Grafting
别名: SVF 얼굴성형, SVF 얼굴 지방이식
SVF facial fat grafting is facial fat transfer with the graft enriched by stromal vascular fraction.
What is SVF facial fat grafting?
SVF facial fat grafting is facial fat transfer in which the injected fat is enriched with stromal vascular fraction isolated from part of the harvested fat. The rationale is the same as for cell-assisted grafting elsewhere: added stromal cells may support graft survival. Evidence for the face comes mainly from small series rather than large controlled trials.
关键事实
| 属性 | 值 | 来源 |
|---|---|---|
| Definition | Cell-assisted lipotransfer: SVF is isolated from half of the harvested fat and recombined with the remaining fat before injection | [1]journalCell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells (Yoshimura K et al., Dermatologic Surgery; Europe PMC record)Wiley / Europe PMC |
| First facial clinical report | 2008, Yoshimura et al. (University of Tokyo), Dermatologic Surgery 34(9); facial lipoatrophy, 3 CAL vs 3 conventional patients | [1]journalCell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells (Yoshimura K et al., Dermatologic Surgery; Europe PMC record)Wiley / Europe PMC |
| Pooled retention difference (all sites) | SVF-enriched grafts: +17.20 percentage points in mean retention vs conventional (95% CI 11.26–23.15); 18 studies, 893 patients; authors call for more standardized RCTs %截至 2026年1月1日 | [1]journalCell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells (Yoshimura K et al., Dermatologic Surgery; Europe PMC record)Wiley / Europe PMC |
| Reported safety | No serious adverse events attributed to SVF enrichment in the included studies (follow-up up to 4 years); minor bruising and swelling; nonrandomized studies at serious risk of bias截至 2025年1月1日 | [2]journalAdipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional OutcomesCureus (PubMed Central) |
| SVF isolation methods | Enzymatic (collagenase) or mechanical; mechanical isolation gives lower total cell yield but comparable viability截至 2025年1月1日 | [3]journalMechanical isolation of stromal vascular fraction from adipose tissue: methods and cellular outcomes: a systematic review and meta-analysisStem Cell Research & Therapy (via PubMed Central) |
| US regulatory position | FDA stated that processing adipose tissue into SVF is more than minimal manipulation, that the same-surgical-procedure exception does not apply, and that a BLA or IND is required截至 2017年8月24日 | [4]governmentWarning Letter: US Stem Cell Clinic, LLC (524470)U.S. Food and Drug Administration |
| Applicable FDA guidance | Regulatory Considerations for HCT/Ps: Minimal Manipulation and Homologous Use (docket FDA-2017-D-6146)截至 2020年7月1日 | [5]governmentRegulatory Considerations for Human Cells, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous UseU.S. Food and Drug Administration |
| Korean institution designation | MOHW designates advanced regenerative medicine institutions (첨단재생의료실시기관) for high-risk cell therapy; MFDS separately licenses cell-processing facilities截至 2026年6月12日 | [6]news줄기세포 가슴성형, 복지부‧식약처 인증기관에서 받으면 ‘안심’Sports Kyunghyang |
概述
SVF facial fat grafting, also called cell-assisted lipotransfer, is autologous fat transfer to the face in which the stromal vascular fraction (a cell mix including adipose-derived stromal cells) is isolated from part of the lipoaspirate by collagenase digestion or mechanical processing and added to the injected fat. It is used for facial lipoatrophy, contour deficits and volume restoration, on the rationale that the cells support graft survival. Systematic reviews report higher retention than plain fat grafting, but most studies are small, heterogeneous and of weak quality. The US FDA treats enzymatically processed SVF as more than minimally manipulated, requiring an IND or biologics licence; in Korea, cell-based procedures may fall under the Advanced Regenerative Bio Act. Readers should verify the isolation method, the provider's regulatory status and how retention was measured.
已验证服务机构
付费展示均有标注。验证与付费无关。SC301의원
SC301의원 (SC301 Clinic) is a plastic surgery clinic in Gangnam, Seoul, South Korea whose official site presents SVF (stromal vascular fraction) fat grafting for the breast and face, liposuction, lifting and cell banking as its main services.
查看机构参考来源
独立来源比例 100% (11/11)- 等级 B · journalCell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells (Yoshimura K et al., Dermatologic Surgery; Europe PMC record) — Wiley / Europe PMC · 访问于 2026年9月20日 · 证据页
- 等级 B · journalAdipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional Outcomes — Cureus (PubMed Central) · 访问于 2026年9月19日 · 证据页
- 等级 B · journalMechanical isolation of stromal vascular fraction from adipose tissue: methods and cellular outcomes: a systematic review and meta-analysis — Stem Cell Research & Therapy (via PubMed Central) · 访问于 2026年9月20日 · 证据页
- 等级 A · governmentWarning Letter: US Stem Cell Clinic, LLC (524470) — U.S. Food and Drug Administration · 访问于 2026年9月20日 · 证据页
- 等级 A · governmentRegulatory Considerations for Human Cells, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous Use — U.S. Food and Drug Administration · 访问于 2026年9月20日 · 证据页
- 等级 D · news줄기세포 가슴성형, 복지부‧식약처 인증기관에서 받으면 ‘안심’ — Sports Kyunghyang · 访问于 2026年9月20日 · 证据页
- 等级 B · academicCell-Assisted Lipotransfer: A Systematic Review of its Efficacy — Aesthetic Plastic Surgery (2024) · 访问于 2026年9月20日 · 证据页
- 等级 B · academicSafety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature review — Stem Cell Research & Therapy (2026) · 访问于 2026年9月20日 · 证据页
- 等级 B · academicAdvancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies — Frontiers in Cell and Developmental Biology (2026) · 访问于 2026年9月20日 · 证据页
- 等级 C · organizationISSCR Guidelines for Stem Cell Research and Clinical Translation — International Society for Stem Cell Research · 访问于 2026年9月20日 · 证据页
- 等级 A · governmentFDA Warns About Stem Cell Therapies — U.S. Food and Drug Administration · 访问于 2026年9月15日 · 证据页