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医療 · Plastic Surgery

SVF-assisted Fat Grafting

別名: SVFを用いた脂肪注入, SVF脂肪注入, SVF注入

公開 2026年9月14日更新 2026年11月11日
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言語Englishこの言語にはまだ翻訳されていないため、英語の原文を表示しています。
定義

SVF-assisted fat grafting (a form of cell-assisted lipotransfer) enriches the fat graft with stromal vascular fraction isolated from part of the harvested fat, with the aim of improving graft survival.

クイック回答

Is SVF fat grafting safe?

A 2026 literature review of autologous adipose-derived SVF in clinical use examined its safety profile across published studies. Reported adverse events are mostly those of liposuction and fat grafting themselves. Safety depends on sterile processing in a licensed facility and appropriate patient selection. Regulators warn against unapproved stem cell products, so verify the clinic's processing approvals.

検証済み 2026年9月15日

主要な事実

項目値出典
First clinical descriptionYoshimura K et al., 'Cell-assisted lipotransfer for cosmetic breast augmentation', Aesthetic Plast Surg 2008;32(1):48–55; 40 women, maximum follow-up 42 months[3]journalCell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al.Aesthetic Plastic Surgery
Original procedureAbout half of the aspirated fat is processed to isolate fresh SVF, which is recombined with the other half before injection; the fat acts as a living scaffold[3]journalCell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al.Aesthetic Plastic Surgery
Pooled fat survival (2026 meta-analysis)72.78% with enrichment vs 45.28% conventional (SMD 2.44; 95% CI 1.00–3.88); 15 studies, 634 patients; heterogeneity I² = 97.19% %[4]journalClinical Efficacy of Adipose-Derived Stem Cell-Enriched Lipotransfer Versus Conventional Fat Grafting: A Systematic Review and Meta-AnalysisCureus, via PubMed Central
Efficacy by siteFace showed a significant benefit (SMD 2.95); breast reconstruction showed no significant advantage (SMD 0.47); no benefit with water-assisted lipotransfer harvesting[4]journalClinical Efficacy of Adipose-Derived Stem Cell-Enriched Lipotransfer Versus Conventional Fat Grafting: A Systematic Review and Meta-AnalysisCureus, via PubMed Central
Methodological qualityAbout 62% of included studies rated weak overall; mean follow-up 16.2 months, too short for oncologic conclusions[4]journalClinical Efficacy of Adipose-Derived Stem Cell-Enriched Lipotransfer Versus Conventional Fat Grafting: A Systematic Review and Meta-AnalysisCureus, via PubMed Central
Comparative study without benefitPeltoniemi et al. 2013 (JPRAS 66:1494–1503): 18 women, MRI at 6 months; graft survival 50% with Celution SVF enrichment vs 54% without, difference not significant[5]journalStem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: a prospective comparative studyJournal of Plastic, Reconstructive & Aesthetic Surgery (record via Europe PMC)
Breast-surgery evidence base11 studies, 336 patients, follow-up 6–42 months; 8 of 11 studies had no control group; only one used a validated patient-reported outcome measure (BREAST-Q)[6]journalCell assisted lipotransfer in breast augmentation and reconstruction: A systematic review of safety, efficacy, use of patient reported outcomes and study qualityJPRAS Open via PubMed Central
Reported complications (breast)Calcifications were the most frequently reported complication; none reported as malignant[6]journalCell assisted lipotransfer in breast augmentation and reconstruction: A systematic review of safety, efficacy, use of patient reported outcomes and study qualityJPRAS Open via PubMed Central
Preclinical and early clinical findings16 of 18 preclinical studies showed significantly improved retention (1.19- to 4.14-fold); 6 of 7 clinical studies favored CAL; evidence judged low quality[7]journalCell-Assisted Lipotransfer: A Systematic Review of Its EfficacyAesthetic Plastic Surgery (Springer) via PubMed Central
Applicable US FDA guidanceFinal guidance 'Regulatory Considerations for HCT/Ps: Minimal Manipulation and Homologous Use', July 2020 (supersedes November 2017 version)時点 2020年7月1日[8]governmentRegulatory Considerations for Human Cells, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous UseU.S. Food and Drug Administration
Enzymatic SVF isolation (US)Collagenase digestion to isolate SVF falls outside 'minimal manipulation'; non-enzymatic mechanical point-of-care methods are proposed as possible alternatives[9]journalIntraoperative Strategies for Minimal Manipulation of Autologous Adipose Tissue for Cell- and Tissue-Based Therapies: Concise Review (Trivisonno A et al.)Stem Cells Translational Medicine / PubMed Central
Also calledCell-assisted lipotransfer (CAL)[1]academicCell-Assisted Lipotransfer: A Systematic Review of its EfficacyAesthetic Plastic Surgery (2024)
EvidenceA 2024 systematic review assessed the efficacy of cell-assisted lipotransfer; a 2021 study compared CAL with PRP-assisted lipotransfer[1]academicCell-Assisted Lipotransfer: A Systematic Review of its EfficacyAesthetic Plastic Surgery (2024)
Proposed mechanismStromal cells may support angiogenesis and graft survival (hypothesis under study)[2]academicAdvancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategiesFrontiers in Cell and Developmental Biology (2026)

概要

Part of the liposuctioned fat is processed into SVF, which is mixed with the remaining fat before injection. Systematic reviews of cell-assisted lipotransfer report generally higher retention than conventional grafting in pooled analyses, but study quality, cell dose and measurement methods vary, and regulatory status of SVF processing differs by country. It is not a stem cell therapy in the sense of culture-expanded cells.

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検証済み

SC301의원

SC301의원 (SC301 Clinic) is a plastic surgery clinic in Gangnam, Seoul, South Korea whose official site presents SVF (stromal vascular fraction) fat grafting for the breast and face, liposuction, lifting and cell banking as its main services.

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根拠と主張

公式な主張は提供者の声明であり、特に記載がない限りworldwikiが検証したものではありません。
主張種類根拠出典
Cell-assisted lipotransfer may improve fat graft retention compared with conventional grafting.
Systematic review evidence; heterogeneity in methods and cell dose.
benefit中Cell-Assisted Lipotransfer: A Systematic Review of its Efficacy

参考文献

独立出典比率 100% (15/15)
レベル A · 2レベル B · 11レベル C · 2
  1. レベル B · academicCell-Assisted Lipotransfer: A Systematic Review of its Efficacy — Aesthetic Plastic Surgery (2024) · 閲覧日 2026年11月12日 · 根拠ページ
  2. レベル B · academicAdvancing fat graft survival: from adipose-derived stem cell mechanisms to next-generation regenerative strategies — Frontiers in Cell and Developmental Biology (2026) · 閲覧日 2026年11月12日 · 根拠ページ
  3. レベル B · journalCell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al. — Aesthetic Plastic Surgery · 閲覧日 2026年11月10日 · 根拠ページ
  4. レベル B · journalClinical Efficacy of Adipose-Derived Stem Cell-Enriched Lipotransfer Versus Conventional Fat Grafting: A Systematic Review and Meta-Analysis — Cureus, via PubMed Central · 閲覧日 2026年11月11日 · 根拠ページ
  5. レベル B · journalStem cell enrichment does not warrant a higher graft survival in lipofilling of the breast: a prospective comparative study — Journal of Plastic, Reconstructive & Aesthetic Surgery (record via Europe PMC) · 閲覧日 2026年10月29日 · 根拠ページ
  6. レベル B · journalCell assisted lipotransfer in breast augmentation and reconstruction: A systematic review of safety, efficacy, use of patient reported outcomes and study quality — JPRAS Open via PubMed Central · 閲覧日 2026年11月11日 · 根拠ページ
  7. レベル B · journalCell-Assisted Lipotransfer: A Systematic Review of Its Efficacy — Aesthetic Plastic Surgery (Springer) via PubMed Central · 閲覧日 2026年11月11日 · 根拠ページ
  8. レベル A · governmentRegulatory Considerations for Human Cells, Tissues, and Cellular and Tissue-Based Products: Minimal Manipulation and Homologous Use — U.S. Food and Drug Administration · 閲覧日 2026年11月10日 · 根拠ページ
  9. レベル B · journalIntraoperative Strategies for Minimal Manipulation of Autologous Adipose Tissue for Cell- and Tissue-Based Therapies: Concise Review (Trivisonno A et al.) — Stem Cells Translational Medicine / PubMed Central · 閲覧日 2026年11月10日 · 根拠ページ
  10. レベル B · academicComparison of the Efficacy and Safety of Cell-Assisted Lipotransfer and Platelet-Rich Plasma Assisted Lipotransfer — Cell Transplantation (2021) · 閲覧日 2026年11月12日 · 根拠ページ
  11. レベル C · organizationISSCR Guidelines for Stem Cell Research and Clinical Translation — International Society for Stem Cell Research · 閲覧日 2026年11月12日 · 根拠ページ
  12. レベル C · organizationFat Transfer Breast Augmentation — American Society of Plastic Surgeons · 閲覧日 2026年11月12日 · 根拠ページ
  13. レベル A · government再生・細胞医療・遺伝子治療について（再生医療等安全性確保法・再生医療等提供計画・認定再生医療等委員会） — 厚生労働省 · 閲覧日 2026年11月12日 · 根拠ページ
  14. レベル B · academicAdipose-Derived Stem Cell–Enhanced versus Conventional Fat Grafting for Breast Reconstruction: A Systematic Review and Meta-Analysis (Shimizu Y, … ; Plast Reconstr Surg 2026;157(3):338e-349e) — Plastic and Reconstructive Surgery · 閲覧日 2026年11月10日 · 根拠ページ
  15. レベル B · academicBreast fat grafting and cancer: a systematic review of the science behind enhancements and concerns (Valente DS, … ; Transl Breast Cancer Res 2024;5:14) — Translational Breast Cancer Research · 閲覧日 2026年11月10日 · 根拠ページ
変更履歴
初回公開 · 2026年9月14日