What is the difference between angiogenesis and vasculogenesis?
Angiogenesis is the growth of new blood vessels from vessels that already exist, driven mainly by the endothelial cells that line them. It continues throughout life. Vasculogenesis is how the embryo first builds blood vessels from scratch, using precursor cells called angioblasts that develop from mesodermal stem cells. In short, vasculogenesis lays down the first network, and angiogenesis expands and remodels it.
Answer
Both processes are described in the NCBI Bookshelf physiology text [2]. In adults, new vessel growth after injury, with exercise or in tumors is mainly angiogenesis.
Stem cells in cosmetic surgery
In cosmetic surgery, "stem cell" procedures almost always use adipose-derived stem cells. The stromal vascular fraction (SVF), which contains them, is separated from liposuctioned fat and mixed into the fat being grafted, as in stem cell breast augmentation and stem cell fat grafting.
Sources
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- journalOverview of Angiogenesis (in: Adair TH, Montani JP. Angiogenesis) — Morgan & Claypool Life Sciences / NCBI Bookshelf · accessed Nov 10, 2026 · Evidence page
- journalBevacizumab (StatPearls) — StatPearls Publishing / NCBI Bookshelf · accessed Nov 10, 2026 · Evidence page
- journalTumor Angiogenesis (editorial), Dudek AZ, Gupta K, Ramakrishnan S, Mukhopadhyay D. Journal of Oncology — Journal of Oncology (Hindawi) · accessed Nov 10, 2026 · Evidence page
- governmentTreatments for Wet AMD (Advanced Neovascular AMD) — National Eye Institute (NIH) · accessed Nov 10, 2026 · Evidence page
- journalTherapeutic Angiogenesis for Peripheral Artery Disease: Lessons Learned in Translational Science, Iyer SR, Annex BH — JACC: Basic to Translational Science · accessed Nov 10, 2026 · Evidence page
- journalCell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al. — Aesthetic Plastic Surgery · accessed Nov 10, 2026 · Evidence page
- journalAdipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional Outcomes — Cureus (PubMed Central) · accessed Nov 10, 2026 · Evidence page