What are the side effects of angiogenesis inhibitors?
NCI lists these common side effects of angiogenesis inhibitors: bleeding, clots in the arteries, high blood pressure, slow wound healing and protein in the urine. Drugs that target VEGF receptors can also cause fatigue, diarrhea, thyroid problems and hand-foot syndrome. Rare but serious problems include tears in the gut wall and fistulas. For bevacizumab, reported rates of high blood pressure range from 19% to 42%.
Answer
For the side-effect list, see [1]. For bevacizumab-specific rates, see [3]. These drugs are prescribed and monitored by specialists.
Stem cells in cosmetic surgery
In cosmetic surgery, "stem cell" procedures almost always use adipose-derived stem cells. The stromal vascular fraction (SVF), which contains them, is separated from liposuctioned fat and mixed into the fat being grafted, as in stem cell breast augmentation and stem cell fat grafting.
Sources
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- journalOverview of Angiogenesis (in: Adair TH, Montani JP. Angiogenesis) — Morgan & Claypool Life Sciences / NCBI Bookshelf · accessed Nov 10, 2026 · Evidence page
- journalBevacizumab (StatPearls) — StatPearls Publishing / NCBI Bookshelf · accessed Nov 10, 2026 · Evidence page
- journalTumor Angiogenesis (editorial), Dudek AZ, Gupta K, Ramakrishnan S, Mukhopadhyay D. Journal of Oncology — Journal of Oncology (Hindawi) · accessed Nov 10, 2026 · Evidence page
- governmentTreatments for Wet AMD (Advanced Neovascular AMD) — National Eye Institute (NIH) · accessed Nov 10, 2026 · Evidence page
- journalTherapeutic Angiogenesis for Peripheral Artery Disease: Lessons Learned in Translational Science, Iyer SR, Annex BH — JACC: Basic to Translational Science · accessed Nov 10, 2026 · Evidence page
- journalCell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells, Yoshimura K et al. — Aesthetic Plastic Surgery · accessed Nov 10, 2026 · Evidence page
- journalAdipose-Derived Stem Cell, Stromal Vascular Fraction, and Regenerative Cell Enrichment in Fat Grafting: A Systematic Review of Safety and Functional Outcomes — Cureus (PubMed Central) · accessed Nov 10, 2026 · Evidence page