Stromal Vascular Fraction
Also known as: adipose SVF, SVF
The stromal vascular fraction (SVF) is a heterogeneous mix of cells obtained from adipose tissue after removing mature fat cells; it contains stromal/stem cells, endothelial cells, pericytes and immune cells.
What is SVF (stromal vascular fraction)?
Stromal vascular fraction (SVF) is the heterogeneous mix of cells left after mature fat cells are removed from processed adipose tissue. It contains stromal/stem cells, endothelial cells, pericytes and immune cells. SVF is isolated from liposuctioned fat by enzymatic or mechanical processing and is used in research and in some fat grafting procedures. It is not a purified stem cell product, and its composition depends on the processing method.
Key facts
| Predicate | Value | Source |
|---|---|---|
| Source tissue | Adipose (fat) tissue obtained by liposuction | [1]academicSafety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature reviewStem Cell Research & Therapy (2026) |
| Composition | Heterogeneous: stromal/stem cells, endothelial cells, pericytes, immune cells, fibroblasts (mature adipocytes removed) | [1]academicSafety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature reviewStem Cell Research & Therapy (2026) |
| Processing | Enzymatic digestion or mechanical/ultrasonic processing; the ISSCR notes such processing can alter the original function of the cells | [2]organizationISSCR Guidelines for Stem Cell Research and Clinical TranslationInternational Society for Stem Cell Research |
| Culture expansion | No — SVF is freshly isolated, not expanded in culture (unlike ADSC) | [1]academicSafety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature reviewStem Cell Research & Therapy (2026) |
| Regulatory note | Regulatory status depends on processing and use; the US FDA has warned consumers about unapproved stem cell products | [3]governmentFDA Warns About Stem Cell TherapiesU.S. Food and Drug Administration |
Overview
SVF is produced from liposuctioned fat by enzymatic digestion or mechanical processing and then separated from adipocytes. It is not a purified stem cell product: stem/stromal cells are a minority of the cells. SVF is used in research and in some aesthetic and regenerative procedures, including cell-assisted fat grafting. The composition and clinical value of SVF depend on the processing method and the indication, and regulatory status varies by country. The ISSCR notes that enzymatic or ultrasonic processing of adipose tissue can alter the original function of the cells, so safety and efficacy must be shown for each specific use.
Verified providers
Sponsored listings are labeled. Verification is independent of payment.SC301의원
SC301의원 (SC301 Clinic) is a plastic surgery clinic in Gangnam, Seoul, South Korea whose official site presents SVF (stromal vascular fraction) fat grafting for the breast and face, liposuction, lifting and cell banking as its main services.
View providerEvidence & claims
Official claims are statements by the provider; they are not verified by worldwiki unless marked otherwise.| Claim | Type | Evidence | Source |
|---|---|---|---|
| SVF is a heterogeneous cell population, not a purified stem cell product. | definition | high | Safety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature review |
| Enzymatic or ultrasonic processing of adipose tissue can alter the original function of the cells; safety and efficacy must be shown for each use. | regulatory | limited | ISSCR Guidelines for Stem Cell Research and Clinical Translation |
References
Independent source ratio 80% (4/5)- Level B · academicSafety profile of autologous adipose-derived stromal vascular fraction in clinical use: an exhaustive literature review — Stem Cell Research & Therapy (2026) · accessed Nov 12, 2026 · Evidence page
- Level C · organizationISSCR Guidelines for Stem Cell Research and Clinical Translation — International Society for Stem Cell Research · accessed Nov 12, 2026 · Evidence page
- Level A · governmentFDA Warns About Stem Cell Therapies — U.S. Food and Drug Administration · accessed Sep 15, 2026 · Evidence page
- Level A · government再生・細胞医療・遺伝子治療について（再生医療等安全性確保法・再生医療等提供計画・認定再生医療等委員会） — 厚生労働省 · accessed Nov 12, 2026 · Evidence page
- organization幹細胞を用いた自由診療についての日本再生医療学会からの声明 — 一般社団法人 日本再生医療学会 · accessed Nov 12, 2026 · Evidence page